Our quality,
your innovation

With over 20 years of experience in consulting, processing and procuring for research organizations nationwide, Bloodworks Bio offers:

• a robust and diverse research donor pool of both healthy and disease state individuals
• customizable donor selection services, including high resolution HLA typing, CMV status, blood type, and more
• IRB approved informed consent and collection protocols
• targeted donor recruitment and program management
• specialized processing and execution of customizable protocols
• assistance with early phase pre-clinical R&D, process and product development, and commercialization
• access to expert medical consulting, clinical collections experts, GMP processing personnel, quality experts and testing specialists.

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Our state-of-the-art apheresis center maintains an established donor database and is a trusted partner to cellular therapy companies nationwide. Our Advanced Cell Processing lab provides comprehensive support for both clinical and non-clinical cell therapy applications, and are capable of supporting a wide range of drug delivery methods (CAR-T, CRISPR and others).

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The Bloodworks Bio Cord Blood program, the first and only in the Pacific Northwest, supports translational research with applications in the clinical setting, including commercial supply and clinical trials. We provide cord blood-derived research products from sourcing to final product, ensuring a quality, customizable product to meet your needs. Both fresh unprocessed cord blood units and frozen processed units are currently available for research use.

Licenses and Accreditations:
FDA license to operate
FDA Establishment Registration for HCT/Ps
FACT accreditation
BLA license (cord blood/cell processing lab)

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Mass Spectrometry

Our mission at the Mass Spectrometry Laboratory at Bloodworks Northwest is to aid researchers in their studies using mass spectrometry, proteomics, and metabolomics. With our state-of-the-art facility we provide sample analysis, training and consultation to investigators within the Blood Center as well as external collaborators.

Instrumentation

• AB SCIEX QTRAP 6500 mass spectrometer system coupled with Waters ACQUITY UPLC I-Class System
• ThermoScientific LTQ Orbitrap Velos hybrid FT mass spectrometer coupled with Waters nanoACQUITY UPLC System
• Thermo-Finnigan LCQ Deca XP Plus mass spectrometer coupled with Agilent 1100 HPLC System

Services

• Characterization and relative quantitation of post-translational modifications and mutations in proteins
• Quantitative measurement of mutations, oxidation, and cleavage of VWF in plasma
• Fibrinogen oxidation and degradation
• Protein profiling
• Quantitative analysis of metabolites
• Analysis of fatty acids and lysophospholipids
• Quantification of polyunsaturated fatty acids and their oxidation products
• Analysis of small molecular thiols and disulfides
• Untargeted metabolomics analysis of biofluids

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Flow Cytometry

The Flow Cytometry Laboratory (Flow Lab) provides cell sorting and analysis services, as well as consultation regarding cytometry experimental design, sample preparation and data analysis. In addition, the staff welcomes the opportunity for external research project contracts.

Instrumentation

The Flow Lab is equipped with FACSAria cell sorter, LSR II cytometer and Amnis ImageStream Mk II imaging cytometry system.

The Flow Lab has been actively involved in ongoing and previous projects addressing bleeding disorder, transfusion complications, coagulopathy in traumatic brain injury, sickle cell disease, and thrombosis, megakaryocytopoiesis, platelet generation, autoimmunity and therapeutic immune modulation for inhibitory antibodies against factor VIII.

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